p53 Impairs Endothelial Function by Transcriptionally Repressing Kruppel-Like Factor 2
نویسندگان
چکیده
منابع مشابه
p53 impairs endothelial function by transcriptionally repressing Kruppel-Like Factor 2.
OBJECTIVE To evaluate if p53 decreases Kruppel-Like Factor 2 (KLF2) expression and determine whether p53-mediated suppression of KLF2 plays a role in p53-induced endothelial dysfunction. METHODS AND RESULTS Endothelial KLF2 mediates endothelium-dependent vascular homeostasis by differentially regulating endothelial genes, leading to an anti-inflammatory and antithrombotic endothelial surface ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2011
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.110.215061